MYH7B Antibody, HRP conjugated

Code CSB-PA015301LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MYH7B Polyclonal antibody
Uniprot No.
Target Names
MYH7B
Alternative Names
Antigen MLAA-21 antibody; cardiac muscle beta isoform antibody; Myh7b antibody; MYH7B_HUMAN antibody; Myosin cardiac muscle beta chain antibody; Myosin heavy chain 7B antibody; Myosin-7B antibody; Slow A MYH14 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Myosin-7B protein (1-176AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in muscle contraction.
Gene References into Functions
  1. The actin-based motor myosin-7b (Myo7b) promotes the accumulation of intermicrovillar adhesion complex (IMAC components at microvillar tips. Myo7b is highly enriched at the tips of microvilli in both kidney and intestinal brush borders, and loss of Myo7b in differentiating intestinal epithelial cells disrupts intermicrovillar adhesion and, thus, brush border assembly. PMID: 27666969
  2. Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [MYH7B] PMID: 23800289
  3. Data suggest that transcription and alternative splicing uncouple the level of expression of MYH7b and miR-499 when their coexpression is not required. PMID: 20154144
  4. MYH7b, the ortholog of slow myosin 2 (SM2) of frogs and birds, is detected as mRNA in heart, slow muscles and extraocular muscles. MYH7b protein is detected only in a subset of fibers, corresponding to slow-tonic fibers, in extraocular muscles. PMID: 19948655
Subcellular Location
Membrane; Peripheral membrane protein.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Tissue Specificity
Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.
Database Links

HGNC: 15906

OMIM: 609928

KEGG: hsa:57644

STRING: 9606.ENSP00000262873

UniGene: Hs.414122

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